The Portuguese giants, who sit in second and third position respectively, are four points adrift of unbeaten leaders Sporting Lisbon.
Having won 15 of their last 16 matches in all competitions, Porto will feel aggrieved that they still remain a considerable distance away from the Primeira Liga pacesetters.
Nevertheless, Sergio Conceicao will have few complaints regarding the performances of a squad who have scored at least twice in their last 10 matches in all competitions.
While it remains to be seen whether being taken to extra time by Nacional in the Taca de Portugal on Tuesday night will impact on his players, Porto will be confident of recording a second win in quick succession over their rivals.
Azuis e brancos prevailed by a 2-0 scoreline in the Portuguese Super Cup on December 23, strengthening the belief that they are performing better than Benfica at this stage of the season.
Midfielder Sergio Oliveira heads into this fixture having scored five goals in his last six matches in all competitions.
Benfica have dropped just two points from their last six outings in Portugal's top flight, but it has only been enough to keep Jorge Jesus's team in third position.
Jesus's side have struggled at times in recent weeks, failing to score more than two goals in any of those league fixtures.
Although Jesus will only care about improving the club's position in the top flight, he will be conscious that his forward line is not firing on all cylinders.
He will hope that a game of this magnitude brings out the best in his attack-minded players, and they should be better for guiding Benfica to a 4-0 win over minnows Estrela in the cup on Tuesday night.
Porto Primeira Liga form: WWWWWW
Porto form (all competitions): WWWWWW
Benfica Primeira Liga form: WWWWDW
Benfica form (all competitions): WLWDWW
Conceicao is expected to revert back to the team which ruthlessly dispatched of Famalicao last weekend.
While Jesus could select the same team which edged past Tondela, there are decisions to be made in the final third.
Barcelona loanee Jean-Clair Todibo will not be considered for a place in the first XI after making his first outing for the club in the same game.
Porto possible starting lineup:
Marchesin; Nanu, Mbemba, Leite, Sanusi; Corona, Oliveira, Uribe, Otavio; Marega, Taremi
Benfica possible starting lineup:
Vlachodimos; Gilberto, Otamendi, Vertonghen, Grimaldo; Everton, Pizzi, Weigl, Rafa; Seferovic, Nunez
We say: Porto 2-1 Benfica
For these two clubs, this is their most important game of the season, and we expect strong performance from both sides. However, Porto will take confidence from their recent cup victory over their rivals, and the home side could prevail from a back-and-forth contest on Friday night.