The home side are already promoted back to the top flight, while the visitors will be hoping that a win boosts their chances of a third successive promotion.
Hearts have been assured of their return to Scotland's top flight for a few weeks now, but the Edinburgh side have been beaten just once at Tynecastle this season, so they will be hoping not to slip up again on the final day of the season.
This weekend's hosts have dominated the division this campaign, currently sitting 23 points clear of nearest rivals Hibernian ahead of the final round of fixtures.
Callum Patterson has continued his strong form for the side in recent weeks, scoring twice in his last four outings to take his total for the season to seven, while Soufian El Hassnaoui has also been among the goals recently.
The team have by far the strongest defence and attack in the division, conceding just 24 goals in 35 matches, while scoring 94 times and keeping 16 clean sheets, earning Neilson a nomination for the PFA Scotland Manager of the Year Award.
Hearts are already guaranteed to finish with the highest ever points total for a club in the second tier, beating city rivals Hibs' previous best set in 1999, but a victory this weekend would give them 93, four more than the old record.
Recent form: WLWLWW
Although they know they will be playing in the playoffs for a place in the Premiership, Rangers will still be pushing for victory, as second place is still up for grabs.
Finishing ahead of Hibernian in the table would move them one step closer to a return to the top flight, as second place will take on the winner of a playoff between third and fourth.
Having worked their way back up from the fourth tier following their financial problems back in 2012 with back-to-back promotions in the last two seasons, the Gers are looking to make it three in a row, and end a three-season absence from the top flight.
Rangers have been third best in attack and defence this season, with both Edinburgh clubs getting the better of them at both ends of the pitch, as the visitors have let in 37 goals, 13 more than this weekend's opponents, while scoring 27 times fewer.
Rangers have been almost as strong away from home as they have been at Ibrox this season, winning more than half of their 17 away fixtures, while losing just four times.
Recent form: WLWDWD
Hearts have not reported any fresh injuries following their win over Cowdenbeath last time out, so the champions should have the option to name an unchanged side.
Hearts possible starting lineup:
Hamilton, McGhee, Ozturk, McKay, McHattie, Walker, El Hassnaoui, Gomis, Sow, Paterson, Nicholson
Rangers possible starting lineup:
Bell, McGregor, McCulloch, Zaliukas, Wallace, Daly, Murdoch, Law, Vuckic, Clark, Miller
Head To Head
This will be the two sides' second meeting in less than a month, with Rangers having secured a 2-1 win at Ibrox in the first week of April, despite finishing the match with 10 men.
Hearts won the first two meetings between these two sides though, including a 2-0 victory in their last meeting at Tynecastle back in November.
However, Rangers have historically been the stronger side, winning 50 of the 75 previous matches between the two clubs, while Hearts have won just 13, and 12 have finished level.
This is typically a fixture that yields red cards, with eight players being sent off when these two sides have met since the 2008-09 campaign.
We say: Hearts 2-1 Rangers
Rangers looked below par last weekend, while Hearts will surely be looking to end the season on a high note ahead of promotion to the top flight. The hosts will also be keen to make amends for defeat to Rangers just a few weeks back, leaving them with three wins in a season over a side that have typically frustrated them. Hearts have been almost untouchable at home, and should have enough to edge it.
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