Real Madrid will be looking to bounce back from Saturday's shock defeat to Cadiz when they open their 2020-21 Champions League campaign at home to Shakhtar Donetsk.
Los Blancos suffered their first league loss of the campaign at home to Cadiz, with Anthony Lozano scoring the only goal of the contest in the 16th minute.
Zinedine Zidane's side will be determined to return to winning ways on Wednesday as they prepare to welcome Ukrainian giants Shakhtar to Spain for what should be an entertaining contest.
Here, Sports Mole rounds up Madrid's latest injury and suspension news ahead of the clash.
Status: Out
Type of injury: Muscular
Possible return date: October 24 (vs. Barcelona)
Eden Hazard has had a terrible time with injuries since arriving at the Bernabeu last summer, and he is currently on the sidelines with a muscular problem. The Belgium international is out of this game but could potentially be available for the clash with Barcelona on October 24.
Status: Out
Type of injury: Mouth
Possible return date: Unknown
Madrid will again be without the services of Mariano Diaz on Wednesday as the forward recently underwent surgery for tonsillitis, which saw him lose eight kilograms in weight during the recovery progress. Diaz has now returned to training but will not be involved in the Champions League clash.
Status: Out
Type of injury: Knee
Possible return date: Unknown
Spain international Dani Carvajal is expected to spend the next five weeks on the sidelines recovering from a knee injury, with the Spaniard damaging his medial collateral ligament during a training session.
Status: Major doubt
Type of injury: Calf
Possible return date: October 21 (vs. Shakhtar)
Alvaro Odriozola has missed Madrid's last two matches with a calf injury that he picked up during a training session earlier this month. The issue is not believed to be serious, though, and the defender has a chance of returning to the starting XI on Wednesday with first-choice right-back Carvajal on the sidelines.
Status: Out
Type of injury: Calf
Possible return date: Unknown
Madrid will again be without the services of Martin Odegaard on Wednesday due to a calf injury, and it is currently unclear when the Norway international might be available for selection.
Status: Minor doubt
Type of injury: Knee
Possible return date: October 21 (vs. Shakhtar)
Sergio Ramos was forced off at the interval of Saturday's clash with Cadiz after suffering a kick to his knee in the first half. The substitution was allegedly precautionary, although the Madrid captain has emerged as a minor doubt for Wednesday's European tie in the Spanish capital.
REAL MADRID'S SUSPENSION LIST
Madrid have no players suspended for the clash with Shakhtar.