Indeed, Betis have been victorious on their last two league visits to the Bernabeu, but the hosts will enter this match full of confidence following a 5-0 win over Leganes on Wednesday night.
Los Blancos have won six, drawn three and lost one of their 10 league games this season to collect 21 points, which is enough for second position in the table, one point off leaders Barcelona.
Here, Sports Mole looks at how Zinedine Zidane's side could line up against Betis.
Marco Asensio and Nacho remain long-term absentees for Madrid due to knee injuries, while Gareth Bale is a doubt for the capital giants due to a troublesome calf problem.
Indeed, Bale has missed Los Blancos's last three matches with the issue that he picked up on international duty, although it is thought that the Wales international could return to the squad this weekend.
James Rodriguez missed the clash with Leganes following the birth of his second child, but the Colombia international should be available this weekend, while Vinicius Junior is an option after being left out of the squad entirely for Wednesday night's five-goal win.
Ferland Mendy for Marcelo is another alteration which could occur at the back, although 18-year-old Brazilian Rodrygo Goes is expected to keep his spot alongside Eden Hazard and Karim Benzema in attack having registered on his full La Liga debut against Leganes. body check tags ::