Real Madrid will switch their attention back to La Liga following their Champions League triumph, which has resulted in a semi-final clash against Borussia Dortmund.
This Sunday, Athletic Bilbao will play host to Los Blancos, who have leapfrogged rivals Atletico Madrid into second place in the table, but they still remain 13 points adrift of leaders Barcelona.
In contrast, Bilbao have had a relatively inconsistent season due to their 14th place in the standings, but a scalp over Real could push them up towards 12th spot.
Bilbao will be without a number of players this weekend due to suspensions suffered by top scorer Aritz Aduriz and midfielder Oscar de Marcos, as well as Carlos Gurpegi and Aymeric Laporte.
Meanwhile, Real have no fresh injury concerns, but Iker Casillas could keep his place on the bench behind Diego Lopez.
Recent form
Athletic Bilbao: LWLWW
Real Madrid: LWWDW
Possible starting lineups
Athletic Bilbao: Iraizoz; Castillo, Dominguez, Iraola, Ekiza; Chimeno, Herrera, Iturraspe; Llorente, Gomez, Muniain
Real Madrid: Lopez; Pepe, Marcelo, Arbeloa, Ramos; Kaka, Alonso, Modric; Callejon, Benzema, Higuain
Sports Mole says: 1-2