Philippe Montanier has made six changes to the Rennes side that lost 2-0 to AS Monaco on Saturday.
Jean-Armel Kana-Biyik, Cheik MBengue, Julien Feret, Adrien Hunou, Anders Konradsen and Nelson Oliveira all drop out of the lineup, while Emerson, Cedric Hountondji, Foued Kadir, Jean II Makoun, Romain Alessandrini and Silvio Romero are all handed starts.
Meanwhile, Christophe Galtier has opted for three alterations to the side that thrashed Reims 4-0 at the weekend.
Fabien Lemoine, Franck Tabanou and Brandao have all been placed on the bench, with Ismael Diomande, Yohan Mollo and Mevlut Erding all handed starts.
Rennes: Costil, Armand, Danze, Emerson, Hountondji, Bakayoko, Kadir, Makoun, Alessandrini, Pitroipa, Romero
Saint-Etienne: Ruffier, Clerc, Ghoulam, Perrin, Sall, Clement, Cohade, Diomande, Hamouma, Mollo, Erding
