Swedish striker Ola Toivonen has been selected up front by Rennes head coach Philippe Montanier, with the player having netted four times in five games for the club so far.
Toivonen is joined in attack by Paul-Georges Ntep and Romain Alessandrini, with a win potentially moving the home side up three places into 10th in Ligue 1.
The visiting Guingamp will line up in a 4-4-2 formation, which is led in attack by the partnership of Mustapha Yatabare and Rachid Alioui.
Rennes: Costil, Mbengue, Boye, Armand, Danze, Kadir, Makoun, Konradsen, Toivonen, Alessandrini, Ntep
Guingamp: Samassa, Martins Pereira, Sorbon, Dos Santos, Kerbrat, Sankhare, Mathis, Giresse, Beauvue, Yatabare, Alioui