Captain Francesco Totti will lead the Roma line against Lazio after shaking off a minor knock.
Fernando Gago, Pablo Osvaldo and Marco Cassetti are all unavailable through suspension, while Aleandro Rosi misses out, after he limped off during the 4-1 defeat at Atalanta last week.
Lazio top-scorer Miroslav Klose starts, after he was rated as doubtful in midweek.
The injury-hit Biancazzurri are without Senad Lulic, Luciano Zauri, Abdoulay Konko, Marius Stankevicius, Tomasso Rocchi, Stefan Radu, Stephen Makinwa, Lorik Cana and Cristian Brocchi.
Roma: Stekelenburg, Taddei, Juan, Heinze, José Angel, Simplicio, De Rossi, Pjanic, Lamela, Totti, Borini. Subs.: Lobont, Rosi, Kjaer, Marquinho, Greco, Bojan, Piscitella.
Lazio: Marchetti, Scaloni, Biava, Dias, Garrido, Ledesma, Matuzalem, Gonzalez, Hernanes, Mauri, Klose. Subs: Bizzarri, Diakité, Sbraga, Candreva, Zampa, Alfaro, Kozac.
