However, anything less than maximum points at Kenilworth Road will leave the Millers needing to beat Cardiff City at the weekend to avoid dropping into the third tier.
Heading into the final five minutes of Saturday's fixture with Blackburn Rovers, Rotherham were facing the prospect of needing at least four points from their final two games.
However, Lewis Wing's late leveller has given his side the opportunity to move ahead of Derby County on goal difference with victory against the Hatters.
Still needing to win at least one of their remaining two games, Paul Warne must consider the pros and cons of going all out for three points when they could benefit from a draw ahead of the weekend.
Nevertheless, Rotherham now have some much-needed momentum after ending their five-match losing streak, recording their first points since April 13.
On a negative note, none of Rotherham's forward line have contributed a goal since three second-half strikes were scored against Queens Park Rangers on that date.
While Luton have long been safe from the drop, Nathan Jones will want to end one of the club's best campaigns in recent memory with a top-10 finish.
The Hatters have been punching above their weight throughout the season and they only require one point from two matches to guarantee 12th spot.
Their latest step in the right direction came on Saturday as they recorded a 1-1 draw with Middlesbrough, extending their unbeaten streak to five games.
Glen Rea got on the scoresheet for Luton with the 26-year-old netting his first goal since the turn of the year.
Despite the short turnaround, Jones will consider selecting the same Luton XI which earned a share of the spoils with Boro.
Luton Town possible starting lineup:
Sluga; Bree, Pearson, Bradley, Naismith; Mpanzu, Rea; Cornick, Dewsbury-Hall, Adebayo; Collins
Rotherham United possible starting lineup:
Blackman; Ihiekwe, Wood, Harding; Olosunde, Barlaser, MacDonald, Wing, Giles; Ladapo, Smith
We say: Luton Town 1-1 Rotherham United
With a draw potentially not doing them any favours, Warne faces a balancing act ahead of this contest. Luton's recent unbeaten streak makes them the favourites, but we feel that the visitors could battle their way to a share of the spoils.
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