Mid-table Samp's only win in four surprisingly came against title-chasing Inter Milan, while the Zebrette have now gone without success since the middle of last month.
During a week of potentially canny moves in terms of recruitment and retainment - with striker Ernesto Torregrossa arriving from Brescia to take the treasured number nine shirt and coveted defender Omar Colley signing a fresh deal until 2025 - Sampdoria have also been recovering from defeat to top-flight rookies Spezia on Monday.
That 2-1 loss in a closely-contested Ligurian derby undermined any sense of progress from turning over Milanese giants Inter just a few days before, leaving the Blucerchiati 11th in the Serie A standings - just three points ahead of their modest local rivals.
Out of character with Ranieri's reputation, his current Samp side play a relatively progressive style of football - leading to a record of 28 goals conceded so far this season, with 26 scored.
Furthermore, evergreen Antonio Candreva, on loan from Inter, has stepped up his game after an unseemly falling-out with Ranieri was resolved last month and he has found the target twice and provided one assist so far this year.
Sampdoria have won all of their last three Serie A encounters with Saturday's visitors Udinese, scoring at least two goals on each occasion, so recent precedent is in their favour as they seek to break into the top half of the table.
Udinese's head coach Luca Gotti believes that his job is not under threat in the wake of a dismal run during the fixture-packed past 30 days, but his team lost for a third time in four at home to Napoli last week.
Now in 15th place, only four points above Torino in the drop zone, Gotti must find a way to reconfigure his plethora of attacking options. Having mixed and matched a wide range of alternatives all season long, none have truly convinced for an outfit with just 18 goals registered to date - one of the least effective attacks in the league.
In their last five games on the road, the Bianconeri's only defeat came against Juventus, so they will retain some hope when heading to Genoa this weekend.
Visiting Samp at Stadio Luigi Ferraris, though, has become one of the club's least-favoured journeys in recent times, as the last Udinese league win away to the Blucerchiati was back in December 2012 - their only victory in the corresponding fixture for 15 league matches.
Sampdoria Serie A form: WWLLWL
Udinese Serie A form: DDLLDL
Once more, Claudio Ranieri will have the luxury of a nearly full-strength squad, with only long-term absentees Alex Ferrari and Manolo Gabbiadini out injured, though Jakub Jankto is suspended - young winger Mikkel Damsgaard should switch to the flank as cover.
Visiting coach Luca Gotti has been dealing with an almost interminable injury list throughout the campaign and - in addition to Mato Jajalo and Ignacio Pussetto, who are both out for the season - Udinese will be without Stefano Okaka, Fernando Forestieri, Sebastian Prodl and Bram Nuytinck.
Sampdoria possible starting lineup:
Audero; Bereszynski, Yoshida, Colley, Augello; Candreva, Ekdal, Thorsby, Damsgaard; Balde, Quagliarella
Udinese possible starting lineup:
Musso; Bonifazi, Becao, Samir; Larsen, De Paul, Arslan, Mandragora, Zeegelaar; Pereyra; Lasagna
We say: Sampdoria 1-1 Udinese
Predicting the outcome of a Sampdoria fixture this season can be fiendishly difficult, as they have been such an unpredictable side.
Many would expect them to bounce back from defeat to surprise package Spezia and see off Udinese on Saturday, but the Zebrette could grind out another away point, as they have drawn several games on the road.