La Roja missed the chance to secure qualification on Saturday night as they were held to a 1-1 draw by Norway.
Here, Sports Mole looks at how Spain could line up at the Friends Arena.
The likes of Jordi Alba, Jose Gaya, Koke, Isco, Dani Parejo, Marco Asensio, Morata and Paco Alcacer are not in the squad for various reasons, and it would be fair to say that there is an unfamiliar look to the current crop of players.
Chelsea goalkeeper Kepa Arrizabalaga conceded the foul that led to Norway levelling from the penalty spot on Saturday night, but the 25-year-old is expected to keep his spot in the side ahead of Manchester United's David de Gea, whose form has dipped at club and international level over the last 12 months.
The bulk of the XI from the clash with Norway should remain the same, with Ramos set to captain the side once again fresh from becoming Spain's record appearance maker last time out. body check tags ::