Spain boss Vicente del Bosque will reportedly hand minutes to both Vitolo and Juanmi during Tuesday's international friendly against Netherlands.
Sevilla's Vitolo and Malaga's Juanmi were both called into the squad off the back of excellent seasons with their respective La Liga clubs.
Neither were involved in Spain's 1-0 win over Ukraine in their Euro 2016 qualifier on Friday, but according to AS, Del Bosque will hand both players their senior debuts against the Dutch.
Vitolo has scored nine times and registered seven assists for Sevilla this season, while Juanmi has hit seven goals in 24 league games thus far.