In contrast, SPAL's relegation from the top flight has already been confirmed and the division's basement side have little to play for in the final couple of weeks.
SPAL never looked likely to mount a late charge towards safety following the end of the enforced shutdown, and their three-year stint in Serie A has now come to an end with four games remaining.
Gli Spallini have now lost five games in succession - their most recent outing ending in a 2-1 defeat to fellow strugglers Brescia - and SPAL's fate was sealed as 17th-placed Genoa defeated Lecce 2-1 to extend their lead over SPAL to 14 points.
A slender victory over Parma just before the lockdown may have given Luigi Di Biagio a false sense of hope before the coronavirus pandemic wreaked havoc across the sporting calendar, but ultimately it was not to be for SPAL and Gli Spallini must pack their bags and prepare for an imminent return to Serie B.
SPAL have only managed to garner one point from a possible 24 since the restart - a hard-fought 2-2 draw with AC Milan - and Di Biagio's men have mustered just 24 league goals during the 2019-20 campaign.
In contrast, Roma are still in a good position for a Europa League spot despite dropping two points in a 2-2 stalemate with Inter Milan last time out.
The result leaves Roma in fifth spot on 58 points - two above Napoli and AC Milan in the race for European football, and Fonseca's side have started to string a respectable set of results together following a three-game winless run in June.
I Giallorossi recorded successive victories over Parma, Brescia and Hellas Verona before the draw with Inter, although Roma will be naturally disappointed by their failure to mount a consistent charge for the top four heading into the final stretch.
Fonseca's men enjoyed a straightforward 3-1 victory over SPAL when the sides last locked horns back in December.
SPAL Serie A form: DLLLLL
Roma Serie A form: LLLWWW
As for Roma, Nicolo Zaniolo has suffered another injury setback and missed out the draw with Inter, and the midfielder is a doubt for this one with a calf problem.
SPAL possible starting lineup:
Letica; Cionek, Vicari, Tomovic, Reca; Strefezza, Dabo, Missiroli, Valoti; Petagna, Floccari
Roma possible starting lineup:
Lopez; Smalling, Mancini, Kolarov; Zappacosta, Veretout, Cristante, Spinazzola; Pellegrini, Mkhitaryan; Dzeko
We say: SPAL 0-3 Roma
SPAL will no doubt want to try and end their season on a high note following an otherwise dismal campaign, but Roma are enjoying a strong spell of form and should record all three points against Serie A's basement side with little difficulty on Wednesday.