Spurs' hopes of reaching the knockout rounds looked bleak at the halfway stage, but they go into the final matchday sitting second on head-to-head away goals above Inter Milan.
A win would therefore seal their progress, but they will be consigned to Europa League football in the New Year if they do not at least match Inter's result against PSV Eindhoven.
Here, Sports Mole looks at how Mauricio Pochettino could line his side up for the crucial showdown.
Out: Mousa Dembele (ankle), Erik Lamela (thigh), Davinson Sanchez (hamstring), Victor Wanyama (knee), Juan Foyth (ineligible), Vincent Janssen (foot)
Doubtful: Serge Aurier (knock), Kieran Trippier (groin)
The biggest dilemma could come at right-back, with Serge Aurier limping off against Leicester to join Kieran Trippier on the sidelines. Both are doubts for this match, which could see Kyle Walker-Peters thrown into the deep end.