Antonio Conte oversaw a 2-1 victory over Leeds United in the Premier League at the weekend and also witnessed his side triumph against Vitesse 3-2 in his first game in charge.
However, Spurs remain three points adrift of leaders Rennes in Group G before they do battle with the Ligue 1 outfit on the final matchday next month.
Here, Sports Mole rounds up all of Tottenham's latest injury and suspension news ahead of the contest.
Type of injury: Thigh
Possible return date: Unknown
Cristian Romero - who is suspended for this fixture anyway - picked up a thigh injury during the most recent international break and is facing a potentially lengthy period on the sidelines.
Status: Major doubt
Type of injury: Knock
Possible return date: November 25 (vs. Mura)
Giovani Lo Celso picked up a knock while on duty with Argentina and was not fit to face Leeds, so the midfielder remains a doubt for the trip to Mura.
TOTTENHAM'S SUSPENSION LIST
Oliver Skipp returns from a domestic ban for this contest, but the injured Romero would be missing this game through suspension after seeing red in the win over Vitesse.
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