Jose Mourinho has a couple of injury issues to contend with for the clash in North London, though multiple changes can be expected anyway with the tie as good as wrapped up.
Here, Sports Mole rounds up all of Tottenham's latest injury and suspension news ahead of the European fixture.
Type of injury: Hamstring
Possible return date: Unknown
Giovani Lo Celso injured his hamstring against Leicester City on December 20 and has not featured since. Mourinho confirmed last week that no return date has been set for the midfielder.
Status: Major doubt
Type of injury: Calf
Possible return date: February 24 (vs. Wolfsberger)
Sergio Reguilon returned from a month-long absence against West Ham, but fellow full-back Serge Aurier is still nursing a calf problem. The Ivory Coast international has missed four matches and is not expected to be back in time for this game.
TOTTENHAM'S SUSPENSION LIST
Tottenham have no players suspended for Wednesday's clash, but centre-back Joe Rodon is ineligible as he was not registered as part of their European squad.