Tottenham Hotspur could be without up to seven players for Thursday's Europa League clash with Galatasaray in Istanbul.
Richarlison will be out for a "while" after he was forced off with a hamstring injury in Spurs' 4-1 win over Aston Villa in the Premier League last weekend.
The Brazilian is joined in the treatment room by Micky van de Ven and Wilson Odobert - who are also nursing hamstring injuries - and both Timo Werner and Mikey Moore who have been ruled out of Thursday's fixture with respective groin and illness issues.
Like Richarlison, Cristian Romero was taken off against Villa with a foot injury and the Argentine has emerged as a major doubt for the trip to Turkey, while Djed Spence will be assessed ahead of kickoff as he closes in on a return from a groin problem.
Should Romero miss out on Thursday, Ben Davies will likely deputise in central defence alongside Radu Dragusin, meaning Destiny Udogie should retain his spot at left-back. Pedro Porro, meanwhile, could be replaced at right-back by Archie Gray.
Ange Postecoglou will consider freshening up his midfield and could recall both James Maddison, Yves Bissouma and Lucas Bergvall at the expense of Dejan Kulusevski, Rodrigo Bentancur and Pape Matar Sarr.
Dominic Solanke scored twice in the second half against Villa and he is poised to retain his place up front with Richarlison sidelined, while Son Heung-min and Brennan Johnson could be forced to start again on the flanks in the absence of both Werner and Moore.
Tottenham Hotspur possible starting lineup: Vicario; Gray, Dragusin, Davies, Udogie; Bergvall, Bissouma, Maddison; Johnson, Solanke, Son body check tags ::
