Middlesbrough, who are led by former Spurs player Jonathan Woodgate, must now try to go one better away from home as they look to pull off an FA Cup upset on their first visit to Tottenham's new stadium.
Here, Sports Mole looks at how the hosts could line up for the contest.
Tottenham's options in certain areas of the field are largely dictated by their injury list, with talisman Harry Kane and Moussa Sissoko sidelined until April and Hugo Lloris also a long-term absentee, although he is closing in on a return.
Mourinho named a strong team for the reverse fixture at the Riverside, but he could make changes with home advantage in his favour this time around.
Japhet Tanganga, who was a surprise inclusion for his Premier League debut against Liverpool, will hope to have done enough to retain his starting spot, but Eric Dier and Jan Vertonghen are also pushing for returns to the XI after sitting out at the weekend.
Christian Eriksen was booed off the field by his own fans following his performance against Liverpool and may be taken out of the firing line for this match, with speculation continue to rage regarding his future.
Son and Lucas, the latter of whom earned Spurs this replay, could lead the line again with the inexperienced Troy Parrott Mourinho's only other striking option.