Spurs have lost three games in a row in all competitions, whereas Norwich picked up a morale-boosting victory over Leicester City last time out.
Back-to-back Premier League defeats to Chelsea and Wolverhampton Wanderers, preceded by a 1-0 loss to RB Leipzig in the first leg of their Champions League last-16 tie, has badly derailed Tottenham's campaign.
The Lilywhites are now seventh in the table, albeit just two points adrift of Manchester United in fifth place, which will likely be enough to seal Champions League football for next season.
Jose Mourinho now faces a huge challenge in attempting to stop the rot and getting his side's campaign back on track, with Wednesday's visit of Norwich now taking on added significance.
Spurs required replays to overcome Middlesbrough and Southampton in rounds three and four respectively, but as from this season all fifth-round fixtures must be settled on the day.
That is good news for Mourinho in many ways given he has complained about his side's fixture list in the wake of losing a number of key men to injury.
A Norwich side in confident mood will be looking to take advantage of Tottenham's recent slump and reach the FA Cup quarter-finals for the first time since 1991-92.
The Canaries have been eliminated at this stage four times since then, most recently in 2011-12, and they have also been knocked out from 13 of their last 15 ties against top-flight opposition.
Friday evening's home win over Leicester has given Norwich's survival hopes a major boost, but the gap on safety is still six points with 10 games to go.
Winning the FA Cup will not be on Farke's list of immediate priorities, though this game does provide City with a chance to pull off a big upset to take into their quest for Premier League survival.
Tottenham Hotspur's FA Cup form: DWDW
Tottenham Hotspur's form (all competitions): WWWLLL
Norwich City's FA Cup form: WW
Norwich City's form (all competitions): LWDLLW
Sessegnon is carrying a hip injury and Lloris has injured his groin, with both players considered major doubts for Wednesday's clash.
Erik Lamela is another who has been struggling for fitness of late, though he is expected to be part of the squad and could even start.
Mourinho reiterated at the weekend that Troy Parrott is still not ready for senior football, but the young striker is among those pushing for inclusion, along with Tanguy Ndombele and Gedson Fernandes.
Christoph Zimmermann remains doubtful, meanwhile, after sitting out the games with Wolves and Leicester over the past fortnight.
Tottenham Hotspur possible starting lineup:
Gazzaniga; Aurier, Alderweireld, Sanchez, Davies; Lo Celso, Winks, Ndombele; Lucas, Alli, Bergwijn
Norwich City possible starting lineup:
Fahrmann; Aarons, Godfrey, Hanley, Lewis; Vrancic, Trybull; Rupp, Stiepermann, Cantwell; Drmic
We say: Tottenham Hotspur 2-1 Norwich City
Tottenham have only progressed from one of their previous four FA Cup ties with Norwich. Defeat for Mourinho's men on Wednesday would be pretty disastrous, but we expect them to dig deep and pick up the win needed to kickstart their campaign.
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