The Spaniard will attempt to ensure that complacency does not become a factor throughout this season, although that is unlikely to enter the mindset of his players ahead of a clash with one of their direct title rivals.
Here, Sports Mole predicts how City could line up for Saturday's fixture at the Etihad Stadium.
Guardiola is likely to have the same set of players to choose from, with Leroy Sane and Benjamin Mendy both sidelined with knee injuries and Fernandinho behind the rest of the group in terms of fitness.
Guardiola also finds himself in a predicament regarding Riyad Mahrez as a result of the Algeria international arguably being the star of the show against the Hammers.
Nevertheless, Bernardo Silva will likely be restored to the team having only been named as a substitute for the fixture at the London Stadium.
Joao Cancelo - a summer arrival from Juventus - also finds himself in contention, although he is unlikely to be introduced for his debut for a game of this magnitude.
The defence should remain the same, with Oleksandr Zinchenko being given an opportunity to improve on a shaky performance in England's capital.
Click here to see how Spurs could line up for this fixture. body check tags ::