Tottenham Hotspur will be looking to bounce back from the heartbreak of their late defeat to Liverpool when they host Crystal Palace in the first match at their new stadium on Wednesday night.
Mauricio Pochettino will be hoping that the long overdue boost from moving home will result in an immediate upturn in form, with Spurs now facing a battle simply to stay in the top four.
Just one point from the last 15 available has left Spurs with a one-point lead over North London rivals Arsenal, who could leapfrog them in the table when they take on Newcastle United on Monday night.
Here, Sports Mole rounds up the latest injury and suspension news ahead of the contest.
TOTTENHAM HOTSPUR'S INJURY LIST
Status: Out
Type of injury: Muscle
Possible return date: Unknown
Eric Dier missed Sunday's defeat to Liverpool after picking up an injury during the international break and, while it is not thought to be a serious problem, Wednesday's match will come too soon for the England midfielder.
Status: Slight doubt
Type of injury: Hip
Possible return date: April 3 (vs. Crystal Palace)
Harry Winks is now back in full training and could play some part in Wednesday's London derby, although Pochettino is likely to be wary about throwing him straight back into the starting XI.
Serge Aurier
Status: Major doubt
Type of injury: Hamstring
Possible return date: April 3 (vs. Crystal Palace)
Serge Aurier lasted just 30 minutes of Ivory Coast's win over Rwanda during the international break and only has an outside chance of featuring in midweek.
Fernando Llorente
Status: Out
Type of injury: Concussion
Possible return date: April 9 (vs. Manchester City)
Fernando Llorente is sidelined with concussion, the protocols for which mean that he will be unavailable in midweek but should be able to return for the first leg of the Champions League quarter-finals.
Erik Lamela
Status: Out
Type of injury: Hamstring
Possible return date: Unknown
Erik Lamela has not played since the Champions League second leg win over Borussia Dortmund on March 5 and will miss this match due to a hamstring injury, the severity of which has not yet been revealed.
TOTTENHAM HOTSPUR'S SUSPENSION LIST
Spurs have no players suspended for this match.