The Lilywhites have collected two points from the last 12 on offer, a run that has seen them slip from the top of the table and out of the top four.
Jose Mourinho may be tempted to make changes to his side on the back of Sunday's 1-1 draw with Wolverhampton Wanderers, with certain players showing signs of fatigue.
Here, Sports Mole looks at how Tottenham could line up against London rivals Fulham.
Giovani Lo Celso has been ruled out of the remainder of Tottenham's festive and new year fixtures, while Gareth Bale missed the draw with Wolves because of a calf strain.
That would be a big call should Mourinho opt to bring Alli in from the cold, but if not now then when for the English playmaker?
Kane is without a goal in three league matches, but he is the second highest goalscorer in London derbies in Premier League history with 35 - only Arsenal legend Thierry Henry has netted more (43).
Watch the Sports Mole Football Shorts prediction for this game below: