Spurs beat North London rivals Arsenal 2-1 at the weekend to keep their European hopes alive, while Newcastle were beaten 2-1 by Watford as their season continues to peter out.
Tottenham could not afford to lose against their bitter rivals if they were to prevent 2019-20 being anything other than a disastrous season for the club.
Out of each cup competition and battling for a top-six finish in the Premier League, Jose Mourinho's first season at the Tottenham Hotspur Stadium has not exactly been a success.
However, the win over Arsenal - secured through a late Toby Alderweireld goal after Son Heung-min had cancelled out Pierre-Emerick Aubameyang's opener - has at least given Spurs a platform to build from.
The victory became even more important 24 hours on, in fact, as Manchester City's two-year ban from European football was overturned, meaning that seventh will no longer be enough for a Europa League qualifying spot.
Instead, Mourinho's men will have to make up a three-point deficit on Wolverhampton Wanderers in sixth with only three games to go - a run of fixtures that includes a trip to fourth-placed Leicester City.
Speaking after the Arsenal match, Alderweireld described the result as a "turning point" in Tottenham's season, coming on the back of some inconsistent results since last month's restart.
Spurs have now won three, drawn two and lost one of their last six matches and, in terms of results since Mourinho succeeded Mauricio Pochettino in November, they are fifth in the form table.
There appears to be light at the end of the tunnel for Tottenham, then, and back-to-back wins for the first time since February will ensure that they have every chance of qualifying for the Europa League - a competition Mourinho intends to win for a third time with Spurs.
The same is not quite true for Newcastle, who have receded over the past couple of weeks since thrashing Bournemouth 4-1 on their travels.
Motivation may be an issue for the Magpies given that they are firmly in mid-table, well clear of relegation but with no hope of finishing in a European spot.
Steve Bruce's side have lost 5-0 to Man City and 2-1 to lowly Watford in their last two matches, the latter seeing them concede two second-half penalties to throw away the points.
They are unbeaten in six home league matches, however, and have lost just three times at St James' Park all campaign - not since 2011-12 have they had a better record.
With Tottenham and Liverpool to play on home soil, either side of a trip to Brighton & Hove Albion, Bruce will be hopeful that his players are motivated enough to prevent their campaign from ending on a low note.
Newcastle's Premier League form: WDWDLL
Newcastle's form (all competitions): DLWDLL
Tottenham's Premier League form: DWLWDW
Tottenham's form (all competitions): DWLWDW
Right-back Serge Aurier is also expected to miss Wednesday's clash following the death of his brother in the early hours of Monday.
Aurier's absence coincides with the return of Japhet Tanganga, who was among the substitutes against Arsenal.
Mourinho pulled off a tactical masterclass against Arsenal by fielding a 4-4-1-1 of sorts, but a return to 4-3-3 is likely against Newcastle, possibly meaning a recall for Erik Lamela.
Elsewhere, Allan Saint-Maximin picked up a knock against Watford and is believed to be touch-and-go for Wednesday's match.
Newcastle possible starting lineup:
Dubravka; Krafth, Lascelles, Fernandez, Yedlin; Saint-Maximin, Shelvey, Bentaleb, Joelinton; Almiron; Gayle
Tottenham possible starting lineup:
Lloris; Tanganga, Sanchez, Alderweireld, Davies; Sissoko, Winks, Lo Celso; Lamela, Kane, Son
We say: Newcastle United 2-2 Tottenham Hotspur
Newcastle have lost back-to-back matches but have been tough to beat on home soil this season. Tottenham have struggled for consistency pretty much all campaign, meanwhile, and we can see them following up their derby victory with a stalemate in the North-East.