Harry Kane continues to lead the line, despite his goalless run in August now spanning 14 matches following his blank on Tyneside.
Andre Schurrle, Kevin McDonald and Cyrus Christie all drop out of the side, replaced by Aboubakar Kamara, Timothy Fosu-Mensah and high-profile signing Andre-Frank Zambo Anguissa, with the latter two making their club debuts.
Fulham have lost eight of the last nine Premier League meetings between the sides, winning the other.
Tottenham Hotspur: Lloris, Trippier, Alderweireld, Sanchez, Vertonghen, Davies, Dier, Eriksen, Lucas, Dele, Kane
Subs: Vorm, Aurier, Rose, Dembele, Winks, Sissoko, Lamela
Fulham: Fabri, Fosu-Mensah, Chambers, Le Marchand, Bryan, Anguissa, Seri, Cairney, Kamara, Mitrovic, Sessegnon
Subs: Rico, Christie, McDonald, Johansen, Kebano, Schurrle, Vietto
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