Sissoko struggled to impress for Tottenham last season following a move from Newcastle, but the 27-year-old has been included in Mauricio Pochettino's first league XI of the 2017-18 season.
As for Newcastle, summer arrivals Javi Manquillo, Florian Lejeune and Christian Atsu are included in Rafael Benitez's team, but Jacob Murphy and Aleksandar Mitrovic are on the bench as Dwight Gayle is picked to lead the line.
Newcastle United: Elliot; Manquillo, Clark, Lejeune, Dummett; Shelvey, Hayden; Ritchie, Perez, Atsu; Gayle
Subs: Darlow, Lascelles, Murphy, Aarons, Mbemba, Merino, Mitrovic
Tottenham Hotspur: Lloris; Walker-Peters, Alderweireld, Vertonghen, Davies; Dier, Dembele; Sissoko, Eriksen, Alli; Kane
Subs: Vorm, Carter-Vickers, Wimmer, Wanyama, Winks, Son, Janssen
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