Tottenham Hotspur and Everton will both go in search of their first wins of the Premier League campaign in Saturday afternoon's showdown in North London.
The Lilywhites had to settle for a 1-1 draw at Leicester City on matchday one, while the Toffees were crushed 3-0 by Brighton & Hove Albion, and here Sports Mole rounds up the team news for both clubs.
TOTTENHAM HOTSPUR vs. EVERTON
TOTTENHAM HOTSPUR
Out: Rodrigo Bentancur (head), Dominic Solanke (ankle)
Doubtful: Fraser Forster (foot)
Sports Mole's predicted XI: Vicario; Porro, Romero, Van de Ven, Udogie; Sarr, Bissouma; Kulusevski, Maddison, Son; Richarlison
EVERTON
Out: Ashley Young (suspended), Chermiti (foot), Nathan Patterson (thigh), Seamus Coleman (calf), James Garner (calf), Jarrad Branthwaite (groin)
Doubtful: James Tarkowski (unspecified)
Sports Mole's predicted XI: Pickford; Holgate, O'Brien, Keane, Mykolenko; Harrison, Iroegbunam, Doucoure, Gueye, McNeil; Calvert-Lewin
For data analysis of the most likely results, scorelines and more for this match please click here.