Valencia have exited the Champions League after a 2-0 loss to Lyon.

In Gary Neville's first match in charge, Valencia had the first chance of the game in the ninth minute but Shkodran Mustafi's header went wide of the target from a corner.

Mustafi put the ball in the net with another header two minutes later, but Aymen Abdennour was adjudged to have committed a foul and the goal was disallowed.

Maxwel Cornet nearly gave Lyon the lead shortly after when he was played in one on one, but the outstretched leg of Jaume Domenech denied the young striker.

Valencia's poor defensive performance encouraged Lyon to attack and Domenech was called into action twice in succession. First, he palmed out a shot from Sergi Darder before Corentin Tolisso's shot was parried behind.

Cornet gave Lyon the lead in the 37th minute when he cut into the box from the right wing before curling the ball into the top corner of the net.

Valencia had a penalty appeal turned down shortly before half time.

Neville's side had two chances on the hour mark but long-range shots from Joao Cancelo and Javi Fuego were saved by Anthony Lopes.

Cornet nearly scored his second goal moments later when Alexandre Lacazette played him in, but Abdennour made a last-ditch tackle to stop the chance.

It was game over in the 76th minute when Tolisso's pass found Lacazette in the box to beat Domenech when one on one.