Los Che, who suffered a 3-1 defeat at Osasuna on Wednesday, are currently 14th in the table, eight points clear of the relegation zone, while Alaves occupy 16th position in Spain's top flight.
Valencia have not finished lower than 12th in Spain's top flight since the 1987-88 campaign, but they are currently 14th in the table, having picked up just 35 points from 32 matches.
There is no getting away from the fact that it has been a desperately disappointing season for Los Che, who are only eight points clear of the relegation zone.
Unless something drastic happens, Javi Gracia's side are not going to be relegated, but they are currently on a run of four matches without a victory, including a 3-1 loss at Osasuna on Wednesday evening.
The six-time Spanish champions are only four points behind ninth-placed Granada and have been relatively strong on home soil this term, picking up 24 points from 15 games while suffering just three defeats.
Valencia also recorded a 2-1 win when the pair last met at Mestalla in October 2019, but the last two league matches between the two sides have finished level, including a 2-2 draw earlier this season.
Alaves, meanwhile, will enter this weekend's contest off the back of successive victories over Huesca and Villarreal, which have moved them out of the relegation zone.
The Basque outfit are currently 16th in the table, three points clear of the bottom three, and another win this weekend would give their hopes of survival a huge boost.
Alaves have only lost two of their last six in Spain's top flight, but they have found it difficult on their travels this term, winning just twice, collecting only 10 points from 15 matches, which is the second-worst record in the division.
El Glorioso sacked Abelardo Fernandez earlier this month after slipping to the bottom of the table, but new head coach Javier Calleja has made a strong start to his reign, and the 42-year-old, who has previously been in charge of Villarreal, will be looking to make it four league games unbeaten this weekend.
Valencia will again be without the services of Thierry Correia this weekend through injury, meaning that there could be a start for Daniel Wass at right-back, while Dutch goalkeeper Jasper Cillessen is still absent.
Valencia possible starting lineup:
Domenech; Wass, Paulista, Diakhaby, Gaya; Musah, Soler, Racic, Cheryshev; Gomez, Guedes
Alaves possible starting lineup:
Pacheco; Navarro, Laguardia, Lejeune, Aguirregabiria; Jota, Battaglia, Pina, Rioja; Perez, Joselu
We say: Valencia 2-2 Alaves
Valencia, despite their troubles this term, have a squad full of talent, one which is capable of triumphing in any match at this level of football. Alaves have been impressive under their new head coach, though, and we are backing the visitors to secure a share of the spoils at Mestalla.
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