Both teams suffered defeats in their most recent outings, with Valencia beaten by a struggling Leganes outfit while Espanyol's losing streak continued against Eibar.
Valencia had started to pick up a few points again following the sacking of Albert Celades, but caretaker manager Voro was forced to witness his side succumb to a Ruben Perez penalty in a 1-0 defeat to Leganes at the weekend.
Valencia have now lost five times since the Spanish top flight was given the green light to resume, and their European hopes have dwindled severely with just two games left to play.
Voro's men now occupy ninth spot with 50 points - four adrift of seventh-placed Real Sociedad in what has been a hugely disappointing campaign for a Valencia side that enjoyed back-to-back top-four finishes in the previous two campaigns.
Los Ches will take on Sevilla - a side that has already guaranteed Champions League qualification for next season - in their final game of the season but Valencia's European hopes may have already be wiped out by then should Real Sociedad enjoy victory over Sevilla in midweek.
Meanwhile, Espanyol are heading down to the Segunda Division without a fight after suffering their seventh defeat on the bounce against Eibar on Sunday.
Los Periquitos fate was sealed well before the game following their 1-0 loss to Barcelona which confirmed their relegation, and Espanyol are simply playing for pride following a truly disheartening season for Francisco Rufete's men.
Espanyol have not played outside the Spanish top flight since the 1993-94 season, but Rufete's men have only managed to accumulate 24 points all season and never looked likely to produce a miraculous turnaround in the second half of the campaign.
However, three of Espanyol's five wins during the 2019-20 campaign have actually come on the road, although Rufete's men have only found the back of the net four times in their last nine La Liga outings.
Los Periquitos are now facing a Valencia side whom they have only triumphed over once in their last eight meetings, and Los Ches enjoyed a 2-1 victory when the clubs locked horns earlier in the campaign.
Valencia La Liga form: LLLDWL
Espanyol La Liga form: LLLLLL
As for Espanyol, Pipa is Rufete's solitary injury concern at the minute, with the right-back unlikely to feature before the end of the campaign.
Valencia possible starting lineup:
Domenech; Florenzi, Gabriel, Diakhaby, Costa; Torres, Parejo, Kondogbia, Soler; Gameiro, Gomez
Espanyol possible starting lineup:
Diego Lopez; Gomez, Espinosa, Cabrera, Vila; Melendo, Roca, David Lopez, Darder; Lei, De Tomas
We say: Valencia 2-0 Espanyol
Valencia will be aware that this is a must-win game if they are to stand any chance of qualifying for next season's Europa League. The result may not matter if Sociedad also triumph in midweek, but given Espanyol's abysmal recent record, we are going for a comfortable home victory.