Ramsey’s unavailability has been a constant theme of Wales’ European Championship qualifying programme, with the 28-year-old yet to play a single minute of the Dragons’ campaign.
The former Arsenal midfielder did train on Wednesday morning after reporting a groin problem, but Giggs’ squad flew to Slovakia without him.
“Anger comes into it of course, but I haven’t got anything to clear my mind about.
“I try and give my best whether here or in Madrid and I will continue to do that.”
Bale’s first Wales goal came at home to Slovakia in 2006 and he was also on target against them during a 2-1 win in Bordeaux at Euro 2016.
“I have scored against them in the past, but it does not affect what will happen in the future,” Bale said.
“I suppose you could say so (whether it’s make or break). But no matter the situation, we want the three points and to go and win the game.
“We understand the situation in the group and know what we need to do.”