Wales boss Chris Coleman has handed starts to both Ethan Ampadu and David Brooks for the friendly with Panama in Cardiff.
The Chelsea and Sheffield United youngsters made their debuts from the bench as Wales lost 2-0 to France on Friday night, but Coleman has decided to place faith in the pair for the clash with the 2018 World Cup participants.
Liverpool attacker Ben Woodburn also comes into the team, while club teammate Danny Ward starts in goal in place of Wayne Hennessey.
Dave Edwards and Tom Lawrence feature in midfield, while Chris Gunter captains the team as the defender makes his 85th appearance, equalling Gary Speed's record for the highest number of caps for an outfield player.
Coleman has reverted to four at the back, with Ben Davies partnering James Chester in the middle and Neil Taylor taking his place at left-back.
Wales: Ward; Gunter, Chester, Davies, Taylor; Ampadu, Edwards, Brooks, Lawrence, Woodburn; Vokes
Panama: Penedo; Murillo, Baloy, Escobar, Ovalle, Cooper, Heraldez, Vargas, Avila, Perez, Torres
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