The visitors will also be aiming to return to winning ways after falling to a disappointing defeat to East Kew in the preliminary round of the FFA Cup last time out.
After a ninth-place finish in the 2019-20 campaign, Western Sydney Wanderers opened the new season with a shock loss to new boys Macarthur.
However, the Wanderers came crashing back to earth in their last outing as they fell to their second home defeat of the season in a 3-2 loss to Adelaide United.
On the other hand, Melbourne City, who finished as runners-up to defending champions Sydney FC last term, have struggled to get into gear this season.
With three defeats and four losses in their seven outings, Patrick Kisnorbo's men occupy 10th position in the table, although they have two games in hand.
The visitors snapped their three-game losing streak in the league when they claimed a 3-2 win over Sydney FC on Tuesday.
However, they followed it with a shock home defeat in the preliminary round of the FFA Cup against East Kew at the Melbourne Rectangular Stadium.
With one win in their last five matches in all competitions, Melbourne City will be looking to find their feet when they travel to the Bankwest Stadium on Tuesday.
Western Sydney Wanderers Australian A-League form: WDDWDL
Melbourne City Australian A-League form: LWLLLW
Melbourne City form (all competitions): WLLLWL
Both teams come into this fixture with relatively clean bills of health, and we can expect each manager to field his strongest XI.
Goalkeeper Vedran Janjetovic is the only guaranteed absentee for the hosts, as he is out with a long-term injury.
Melbourne City midfielder Nuno Reis is a doubt after hobbling off in the 64th minute with a slight injury against Sydney FC.
Twenty-eight-year-old forward Andrew Nabbout is expected to make his second appearance this term, after making his return from a hamstring injury against the Sky Blues.
The visitors were impressive against Steve Corica's men, and Kisnorbo will likely stick to the same starting XI on Tuesday.
Western Sydney Wanderers possible starting lineup:
Margush; McGowan, Aquilina, Gordon; Georgievski, Dorrans, Baccus, Russell; Muller, Ibini-Isei, Cox
Melbourne City possible starting lineup:
Glover; Jamieson, Good, Griffiths, Garuccio; Tilio, Gomulka, Berenguer; Noone, Maclaren, Metcalfe
We say: Western Sydney Wanderers 2-0 Melbourne City
After contrasting starts to the league campaign, the host have proven to be the better side. They should be able to grab all three points as they take on a Melbourne City side who have struggled for results so far.