Brentford recall Alex Pritchard for their final game of the season after the midfielder shook off a calf injury to take his place in Mark Warburton's side.
However, strikers Chris Long and Scott Hogan have both failed to recover from leg injuries of their own and miss out.
Wigan, who have already been relegated, hand goalkeeper Lee Nicholls his first start of the season, and striker Billy McKay his first start.
They are without midfield duo James McClean and Martyn Waghorn, who both serve suspensions.
Brentford: Button; Odubajo, Dean, Tarkowski, Bidwell; Pritchard, Douglas, Jota, Diagouraga; Judge, Gray.
Wigan Athletic: Nicholls; Maguire, Pearce, Bong, Boyce; Chow, Bo-kyung, Perch, Cowie; McKay, Fortune.
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