Meanwhile, the home side welcome the Premier League club to Victory Park having already defeated three EFL clubs on the way to the last 32.
With Wolves having had to make do without Raul Jimenez in recent weeks, it has been easy for their inconsistency to be put down to issues in the final third of the pitch.
However, Saturday's 3-2 defeat at home to rivals West Bromwich Albion highlighted that Wolves are under-performing in all areas, particularly in defence, where they look far from the well-drilled outfit which has recorded successive seventh-placed finishes in the Premier League.
Taking the risk of switching to a back four has not paid off for Nuno Espirito Santo, whose substitution of skipper Conor Coady versus the Baggies hinted that reverting to a defensive three is not far away.
While Nuno may have previously envisaged resting certain players for this contest, the Portuguese will see this as an opportunity to lift the mood among a squad who could be sucked into a relegation battle.
Although a few alterations could be made, Nuno will want to see a change in mentality with important away games at Chelsea and Crystal Palace to come before the end of the month.
Chorley's victory over Wolves in 1986 will feature heavily in the media ahead of this contest, but the non-league side's current team will be in no mood for nostalgia as they prepare for the biggest fixture of their careers.
Few people will dispute that Wolves should cruise into a fifth-round tie with either Southampton or Arsenal, although Jamie Vermiglio will drill into his players that they are capable of causing another upset.
With Wigan Athletic, Peterborough United and a youthful Derby County already being dispatched, they will hold no fear when standing in front of a squad full of international players and prospects.
While Wolves spent last week losing to their neighbours, Chorley came from behind to run out 3-2 victors over Farsley Celtic, moving them up to ninth place in the National League North.
Chorley FA Cup form: WWWWW
Chorley form (all competitions): WWLWLW
Wolverhampton Wanderers FA Cup form: W
Wolverhampton Wanderers form (all competitions): DLDWLL
Vermiglio may look to field the same side which easily defeated Derby in the last round.
Chorley possible starting lineup:
Urwin; Birch, Leather, Halis, Baines; Newby, Tomlinson, Calveley, Shenton; Hall, Cardwell
Wolverhampton Wanderers possible starting lineup:
Ruddy; Boly, Coady, Saiss; Hoever, Dendoncker, Neves, Ait-Nouri; Gibbs-White; Silva, Cutrone
We say: Chorley 1-3 Wolverhampton Wanderers
After Wolves failed to impose themselves physically against West Brom, Chorley are likely to bombard the visitors during the early stages. However, regardless of their success, we still expect the Premier League side to eventually show their class, particularly in the final third of the pitch.
Top betting tip
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