England will be eager to record a win over South Africa when the two sides meet at Twickenham on Saturday.
The hosts, who were defeated by Australia last weekend, have failed to beat the Springboks in their last 10 attempts.
However, Stuart Lancaster's side managed to draw the final game of their summer tour in Port Elizabeth having lost the previous two.
Meanwhile, South Africa have enjoyed a successful start to the Autumn Internationals thanks to wins against Ireland and Scotland.
England have made six changes for the encounter, with Joe Launchbury making his first Test start.
Tom Wood replaces Tom Johnson and Ben Youngs is given the nod over Danny Care at scrum-half.
South Africa coach Heyneke Meyer has decided to stick with the same starting lineup that saw off Scotland 21-10 last weekend.
Recent form:
England: WLLDWL
South Africa: LLWLWW
Lineups:
England: Goode; Ashton, Tuilagi, Barritt, Brown; Flood, B Youngs, Corbisiero, T Youngs, Cole, Launchbury, Parling, Wood, Robshaw, Morgan,
Replacements: Paice, Wilso, Vunipola, Botha, Haskell, Care, Farrell, Joseph
South Africa: Kirchner; Pietersen, De Jonghde, Villiers, Hougaard; Lambie, Pienaar, Steenkamp, Strauss, Du Pleassis, Etzebeth, Kruger, Louw, Albert, Vermeulen
Replacements: Brits, F Van der Merwe, Cilliers, W Van der Merwe, Coetzee, Jantjies, Taute, Mvovo
Sports Mole says: England's autumn misery to continue
