Toby Flood and Ben Foden have been recalled to the England squad to face Wales in Cardiff this Saturday.
Johnny Wilkinson and Delon Armitage make way as Martin Johnson aims to give as many of his provisional squad a chance to prove themselves before September's World Cup in New Zealand.
Captain Lewis Moody is sidelined having picked up a knee injury, with Mike Tindall expected to replace the Bath flanker as captain.
England beat Wales 23-19 last Saturday at Twickenham.