England and Scotland collide on Saturday in an eagerly-awaited opener to their 2021 Guinness Six Nations campaigns. Here the PA news agency examines five talking points heading into the match.

150 years of hurt

Rugby's oldest rivalry reaches a historical milestone when England and Scotland clash in the 150th anniversary of their first meeting in Edinburgh in 1871. The fixture has been dominated by the red rose, who have won 76 of the 138 previous encounters. Eddie Jones' men are odds-on favourites to dent hopes of a Scottish resurgence, but a dramatic 38-38 draw two years ago will rid the champions of any complacency.

Pride of England

Jones has sounded a note of defiance by reminding Scotland they do not have a "monopoly on pride" in response to the mistaken belief that England are incapable of the passion displayed by their Celtic rivals. It was a reminder that Gregor Townsend's side face resolute opponents determined to launch their title defence with a statement victory. A mischievous Jones also questioned whether Scotland would fold beneath their own expectations amid the positive noises radiating from the underdogs' camp this week.

Testing time for the Sarries spine

For all England's conviction that their influential Saracens contingent will be ready, the fact that all but Billy Vunipola have not played since December is a concern heading into the Twickenham showdown. The spine of the team – hooker Jamie George, lock Maro Itoje, number eight Vunipola, fly-half Owen Farrell and full-back Elliot Daly – have been inactive for two months. No matter how intense England's training, it will be unable to match the ferocity of the opening exchanges against spirited visitors.

Fearless Finn

"Free and fearless" is one of the descriptions of Finn Russell's attacking genius issued by England this week in full understanding that the Racing 92 general has the keys to unlock their defence. Two years ago it was Russell's vision that inspired Scotland to their remarkable comeback after falling 31-0 behind in a riotous afternoon at Twickenham. His range of passing and array of kicks is unique amongst any playmaker in the game today and he must be denied the freedom to ignite his backline.

Best of enemies

Best friends will become unflinching enemies when Ollie Lawrence and Cameron Redpath face off down the inside centre channel. Lawrence provides England with call carrying muscle while Redpath is a more inventive 12. The pair are former England Under-20 team-mates and Jones will be hopeful Redpath wilts on his debut having failed to cap the Bath playmaker after picking him in his squad for the 2018 tour to South Africa, only for a knee injury to intervene.