Stuart Lancaster has called up Manu Tuilagi and Courtney Lawes to his 30-man Six Nations squad ahead of England's clash with Wales at Twickenham on February 25.
Tuilagi and Lawes missed England's victories over Scotland and Italy through injury.
Tuilagi returned from a hamstring injury in Leicester's Premiership defeat to Exeter on Saturday.
Lawes started Northampton against Gloucester on Saturday having recovered from a knee problem.
Toby Flood also rejoins the England squad, having been released last week to recover from a knee injury.
Lancaster is expected to name his match-day XV on Thursday, February 23.