Harlequins director of rugby Conor O'Shea has described Saturday's trip to Worcester Warriors in the Aviva Premiership as a "huge game" for his side.
A win for the champions at Sixways Stadium will see them secure a place in the end-of-season playoffs.
"It's a huge game for us," O'Shea told the club's official website. "We know if we win we're in the top four, which is where we want to be."
Quins narrowly defeated the Warriors 22-19 when the two teams met at Twickenham Stoop earlier in the season.