England centre Brad Barritt and flanker Tom Croft will miss the rest of the Six Nations campaign due to injury.
Barritt injured his ankle during Saracens' 26-17 victory over Wasps on Sunday having been expected to be recalled to the England squad.
Croft, meanwhile, dislocated his shoulder during Leicester Tigers' 16-12 victory over Newcastle Falcons.
England play Scotland at Twickenham on Saturday and finish the Six Nations at home to France a week later.