Defending champion Novak Djokovic and five-time winner Roger Federer made it through to round four.
Johanna Konta is the last Brit standing having made the second week for a third straight grand slam.
Here, PA looks back at day five and forward to day six at the US Open.
Shot of the day
Alex de Minaur's pick-up and volley had the Grandstand crowd on its feet.
Quote of the day
Shock of the day
Seventh seed Kei Nishikori, a finalist here in 2014, was dumped out in four sets by Australian De Minaur.
Brit watch
Coco Gauff and Caty McNally thrilled a packed Court Five with their sojourn into the doubles, a 7-6 6-2 win over Julia Goerges and Katerina Siniakova.
Fallen seeds
Men: Kei Nishikori (7), Nikoloz Basilashvili (17)
Women: Anastasia Sevastova (12), Sofia Kenin (20), Maria Sakkari (30), Dayana Yastremska (32), Zhang Shuai (33)
Saturday's order of play
Arthur Ashe Stadium:
Caroline Wozniacki v Bianca Andreescu
Hyeon Chung v Rafael Nadal
Naomi Osaka v Coco Gauff
Andrey Rublev v Nick Kyrgios
Louis Armstrong Stadium:
Taylor Townsend v Sorana Cirstea
Julia Goerges v Kiki Bertens
Alexander Zverev v Aljaz Bedene
Gael Monfils v Denis Shapovalov
