Arsene Wenger has made nine changes to his Arsenal starting XI ahead of their Europa League Group H trip to BATE Borisov on Thursday afternoon.
Mohamed Elneny and Shkodran Mustafi are the only players to retain their starting spots from the team's 2-1 home win over West Bromwich Albion on Monday night.
Jack Wilshere makes his first European start since 2014, while Olivier Giroud and Theo Walcott also come into the team.
Youngsters Ainsley Maitland-Niles and Reiss Nelson start at full-back, while David Ospina is selected in between the sticks, with third-choice goalkeeper Matt Macey on the bench.
BATE Borisov: Scherbitski, Rios, Gajduchik, Milunovic, Polyakov, Aleksandr Volodjko, Dragun, Gordeichuk, Ivanic, Stasevich, Rodionov
Subs: Veremko, Yablonskiy, Berezkin, Signevich, Tuominem, Baha, Maksim Volodjko
Arsenal: Ospina, Holding, Mertesacker, Mustafi, Willock, Elneny, Nelson, Maitland-Niles, Walcott, Wilshere, Giroud
Subs: Macey, Dasilva, Gilmour, McGuane, Dragomir, Akpom, Nketiah
Follow all the action from the Borisov Arena with Sports Mole's live match commentary.