The Dutch Eredivisie leaders were without their leading marksman through suspension for last month's first leg, which finished goalless.
Eindhoven will have to make do without their Uruguayan Under-21 international forward Gaston Pereiro, however, as he picked up a red card with 20 minutes remaining in the reverse fixture.
That means a staring role for 24-goal striker Antoine Griezmann, although Atleti will be without the services of injured duo Tiago Mendes and Stefan Savic for this big showdown in the Spanish capital.
Atletico head into the match unbeaten in their last eight games, while opponents PSV have suffered just one defeat in their last 25.
Atletico Madrid: Oblak, Godin, Filipe Luis, Juanfran, Gimenez, Koke, Fernandez, Gabi, Saul Níguez, Griezmann, Carrasco
Subs: Moya, Gamez, Lucas Hernandez, Kranevitter, Correa, Torres, Vietto
PSV Eindhoven: Zoet, Isimat-Mirin, Moreno, Arias, Bruma, Propper, Guardado, van Ginkel, de Jong, Locadia
Subs: Pasveer, Brenet, Schaars, Hendrix, Narsingh, Lestienne, Jozefzoon
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