Barcelona have suffered a double injury blow after Frenkie de Jong and Pedri were forced off in the goalless draw with Athletic Bilbao at San Mames.
The Catalan giants played out a stalemate in Sunday's league fixture as they missed the chance to close the eight-point gap to leaders Real Madrid.
Barcelona's failure to claim all three points was compounded by the fact that both De Jong and Pedri picked up injuries in the first half.
De Jong had to be withdrawn in the 26th minute after awkwardly landing on his ankle following a challenge for a high ball.
The Dutchman, who was making his 150th Barcelona appearance, could not continue due to the issue and had to be replaced by 20-year-old midfielder Fermin Lopez.
De Jong has already missed around two months of the campaign due to an ankle issue, and he now appears to be a major doubt for the second leg of the Champions League last-16 tie against Napoli, which is set to take place at Montjuic on March 12.
Pedri is also bracing himself for a spell on the sidelines after he was forced off in the closing stages of the first period at San Mames.
The Spain international appeared to pull up with his third muscle injury of the season and was visibly distraught as made his way to the bench.
Pedri was sidelined for two months at the start of the season due to a hamstring problem, before another muscle issue kept him out of three competitive games across December and January.
Barcelona will now wait to establish the extent of the injuries to De Jong and Pedri, but Xavi had admitted that "it doesn't look good" for the pair.
Speaking after the game, Xavi told reporters: "The injuries affected the team because Frenkie and Pedri are two important players for how we want to play.
"Pedri's been coming good again, he trained really well this week. It's such a shame. Frenkie, too. He is heavily involved in our play. They are two big losses. It doesn't look good. We missed them today and we are going to miss them. Hopefully, it's for less time than expected."
De Jong has made 27 appearances for Barcelona this season, while Pedri has featured in 23 matches throughout the campaign.
Barcelona, who occupy third place in La Liga, will turn their attention to Friday's home meeting with Mallorca, before they prepare for the return leg against Napoli in the Champions League. body check tags ::
