Ronald Koeman's side are currently seventh in the table with seven points from three matches, while Granada have picked up just two points from four matches to sit 17th, and here Sports Mole rounds up the team news.
Doubtful: Samuel Umtiti (muscle)
Sports Mole's predicted XI: Ter Stegen; Dest, Araujo, Pique, Balde; Roberto, Busquets, F de Jong; Coutinho, L de Jong, Depay
Out: Neyder Lozano (leg)
Sports Mole's predicted XI: Maximiano; Duarte, Sanchez, Abram; Arias, Gonalons, Montoro, Monchu, Neva; Suarez, Machis