However, head coach Ernesto Valverde must deal with a number of absentees through both injury and suspension, seeing two men sent off in the clash at Camp Nou.
Here, Sports Mole looks at how Barca could line up for Saturday's showdown.
Marc-Andre ter Stegen's presence in goal is a near certainty, but the back line in front of him is likely to be significantly less settled. Valverde has little option but to field a centre-back pairing of Clement Lenglet and Jean-Clair Todibo, given the absence of any alternatives.
In midfield, the head coach appears to have stumbled across a winning combination, with Frenkie de Jong and Arthur Melo's technical quality dovetailing well with Arturo Vidal's energy and thrust. However, keeping Sergio Busquets on the bench would prove a big call from Valverde, but the success of the aforementioned trio should keep them their places.
Messi and Luis Suarez are certain to retain their places in the front three, but Dembele's red card opens the door for big-money singing Antoine Griezmann to return to the side, albeit in an unfavoured left-wing role.