The Spanish champions suffered a 3-2 defeat to Atletico Madrid in the semi-finals of the Spanish Super Cup last time out, though, while they were held to a 2-2 draw by Espanyol in their last league match.
Here, Sports Mole looks at how the hosts could line up against Granada on Sunday night.
Barca will be without the services of Luis Suarez following knee surgery, while fellow attacker Ousmane Dembele remains on the sidelines with a thigh issue.
Key midfielder Frenkie de Jong is also out through suspension following his red card against Espanyol, but Arthur has returned to training following a recent groin problem and could make the bench.
Marc-Andre ter Stegen's knee issue has also settled, meaning that the club's number one goalkeeper is expected to return to the sticks in place of Neto.
Arturo Vidal is being tipped to earn a spot alongside Ivan Rakitic and Sergio Busquets in central midfield, although Setien also has the option of moving Sergi Roberto into the middle of the park and bringing Nelson Semedo in at right-back.