The Spanish champions have beaten Villarreal and Espanyol in their last two matches to move to within a point of league leaders Real Madrid in the table.
Los Blancos will have the chance to open up another four-point advantage on Friday night, though, which would pile the pressure on Barca ahead of the clash at Estadio Municipal Jose Zorrilla.
Here, Sports Mole looks at how Quique Setien's side could line up against 14th-placed Valladolid, who will enter the match off the back of a 2-1 defeat at Valencia.
Barca will again be without the services of Ousmane Dembele due to a long-term hamstring injury, while Ansu Fati is suspended due to the red card that he picked up against Espanyol on Wednesday night.
Defenders Samuel Umtiti and Junior Firpo remain doubts with knee and hip problems respectively, but Frenkie de Jong is allegedly in line to make a timely return for the Catalan giants.
De Jong has been out since the middle of June with a calf issue, but the Netherlands international has now returned to training and is expected to return to the middle of the park.
Setien is unlikely to take any chances in the final third of the field, though, with Antoine Griezmann set to earn another start alongside Lionel Messi and Luis Suarez, who scored the only goal of the game against Espanyol.