Bayern Munich have made one change to the side that beat Nuremburg in the Bavarian derby on Saturday, with Toni Kroos replacing Thomas Muller.
Mario Mandzukic remains the solitary striker up front.
Hamburger SV, meanwhile, make three changes, with Jonathan Tah, Thomas Rincon and Ivo Ilicevic all coming into the side.
The future of Hamburg head coach Bert van Marwijk has been the subject of boardroom discussion in the last few days.
Bayern Munich: Neuer; Dante, Rafinha, Boateng, Alaba; Thiago, Robben, Götze, Lahm, Kroos; Mandzukic
Hamburger SV: Adler; Lam, Tah, Westermann, Jansen; Badelj, Rincon, John, van der Vaart, Ilicevic; Calhanoglu