Freiburg manager Christian Streich has been forced into one change from the team that beat Stuttgart 3-0 on Saturday, as Mensur Mejdza misses out through suspension after picking up his fifth yellow card of the season.
Johannes Flum will start, while Matthias Ginter and Immanuel Hohn are both out with injury.
Bayern Munich welcome back Mario Gomez to their starting lineup, after he scored within seconds on his return in the 5-0 victory over Hannover.
However, the league leaders are without the injured Arjen Robben and Emre Can.
Freiburg:Baumann; Sorg, Flum, Diagne, Hedenstad; Schmid, Schuster, Makiadi, Caligiuri; Rosenthal, Kruse
Bayern Munich:Neuer; Lahm, Dante, Badstuber, Alaba; Javi Martinez, Shaqiri; Muller, Kroos, Ribery; Gomez